Tissue Repair Response as a Function of Dose in Thioacetamide Hepatotoxicity
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چکیده
منابع مشابه
Tissue repair response as a function of dose in thioacetamide hepatotoxicity.
The purpose of the present study was to establish a dose-response relationship for thioacetamide (TA), where tissue regeneration as well as liver injury were two simultaneous but opposing responses. Male Sprague-Dawley rats were injected intraperitioneally with a 12-fold dose range of TA, and both liver injury and tissue repair were measured. Liver injury was assessed by serum enzyme elevations...
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15 صفحه اولEffect of an antimitotic agent colchicine on thioacetamide hepatotoxicity.
In an earlier study we established that timely and adequate tissue repair response following the administration of a six-fold dose-range of thioacetamide (TA; 50, 150, and 300 mg/kg) prevented progression of injury and led to recovery and animal survival. Delayed and attenuated repair response after the 600 mg/kg TA dose resulted in a marked progression of injury and 100% lethality. The objecti...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1995
ISSN: 0091-6765
DOI: 10.2307/3432546